A con artist takes on the job of pretending to be one of the long-lost sisters of a young and rich woman. As she navigates a world of cunning and lies, she learns about right and wrong, love and family, and spectacular truths about herself.

Serien viser en masse forskellige mordsager som for det meste foregår i Las Vegas. Herefter skal CSI holdet bedre kendt som "Las Vegas Crime Lab" opklare mordet og finde morderen.

Kate and Liam's relationship is in jeopardy because of their long-distance relationship. Kate is busy with her career as a fashion stylist in Milan, while Liam is struggling to revive his music career. Will their relationship survive despite the obstacles, including the presence of a new person in their lives?