16-year-old Cassie Sullivan tries to survive in a world devastated by the waves of an alien invasion that has already decimated the population and knocked mankind back to the Stone Age.

Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.

An awkward, telekinetic teenage girl is the object of relentless bullying at school and an oppressively religious mother at home.

Georgia and her boyfriend Sam go on a treacherous journey to escape their country, which is caught in an unexpected war with artificial intelligence. Days away from the arrival of their first child, the couple must face No Man’s Land—a stronghold of the android uprising—in hopes of reaching safety before giving birth.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.