In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.

After his career is destroyed, a brilliant but arrogant surgeon gets a new lease on life when a sorcerer takes him under her wing and trains him to defend the world against evil.

A teenager finds himself transported to an island where he must help protect a group of orphans with special powers from creatures intent on destroying them.

In the near future, a weary Logan cares for an ailing Professor X in a hideout on the Mexican border. But Logan's attempts to hide from the world and his legacy are upended when a young mutant arrives, pursued by dark forces.