After their late former Captain is framed, Lowrey and Burnett try to clear his name, only to end up on the run themselves.

Now fully revealed as the ultimate threat to existence, the Anti-Monitor wages an unrelenting attack on the surviving Earths that struggle for survival in a pocket universe. One by one, these worlds and all their inhabitants are vaporized! On the planets that remain, even time itself is shattered, and heroes from the past join the Justice League and their rag-tag allies against the epitome of evil. But as they make their last stand, will the sacrifice of the superheroes be enough to save us all?

Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.

Hostage negotiator Alan Bender is called to rescue the president from a kidnapping, only to find himself also mediating to save his wife and marriage.

A listless Wade Wilson toils away in civilian life with his days as the morally flexible mercenary, Deadpool, behind him. But when his homeworld faces an existential threat, Wade must reluctantly suit-up again with an even more reluctant Wolverine.