When Nergal comes to tell the guys about his new pizza joint, Grim thinks he can do better by using his Granny's recipe. A pizza war ensues between Nergal's Pizza and Grim's Pizza, with each pizzeria launching TV ads and discrediting each other. Nergal Jr. uses his shape-shifting abilities to infiltrate Grim's pizza and replace Granny Grim's hot sauce with a "ghastly elixir". The result is pizzas becoming monsters and attacking the city, and the citizens developing parasites similar to Nergal. Nergal and his family leave the city just as Grim's sauce explodes.

As General Skarr has trouble finding a job, the recruiter tells him to attend anger management classes if he wants to work again. Skarr finds out Mandy and Grim are attending too, Mandy for staring at the school monitor, and Grim for enjoying his job too much. The instructor of the class, Larry, turns out to be a peace-loving, short man riding a tricycle, who teaches the trio ways to calm down when angered, including counting to ten, and using harmless weapons to let go of their anger. Larry invites Billy to the class, and Mandy, Grim, and Skarr all manage to contain themselves; however, Larry himself suffers an episode of rage over a parking space and he is arrested.

When Mandy finds Billy playing with Grim's gigantic dog, Cerberus, she tells Grim to keep Billy under tight control because she needs a good night of sleep to be ready for the next day's test. With a little persuasion from his own dad, Billy tries to wake up Mandy at night, so she will fail the test and he can score higher than her for the first time. After Grim spends the night guarding Mandy's house from Billy, the latter succeeds in waking up Mandy. It is revealed that this Mandy is in fact Irwin, used as a decoy by the real Mandy, who slept in her dog's house. Mandy passes the test, and Grim is punished for not guarding her properly.

A scene of Endsville two weeks into the future shows a dystopian world ruled by the "Lord of Horror", who wields the all-powerful artifact known as "Horror's Hand". At the same time, two robotic replicas of Billy and Mandy are sent into the past, to stop the real Billy and Mandy from interfering with the current events.orror's Hand to rule the world.

When Irwin lacks the courage to ask Mandy to go with him to the Valentine's Day school dance, he tells Nergal Jr. to do it for him. Mandy mistakes Junior's invitation for his own, and surprisingly accepts to go with him, which naturally makes Irwin jealous. With the ill advice received from his father, to be possessive with Mandy, at the dance Junior becomes overprotective of her, that eventually he and Irwin start fighting, throwing punch at each other and ruining the ball. It is revealed that this was Mandy's true intention all along so that no one could enjoy Valentine's Day.

On a rainy day, giant spiders appear in Billy and Mandy's school and start kidnapping the children one by one. Grim presumes this is somehow related to his past, but does not figure it out until he receives a message saying that Velma, the Spider Queen, an old good friend from high school, is responsible for it. Meanwhile, Billy meets with Jeff the Spider, who informs him that he is precisely marrying Velma. After trying to recover a talking carton of chocolate milk from Jeff, Billy and Jeff get into a fight, and Jeff looks angrier than ever before.