After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After eight people are fatally poisoned at a deli in New York City, special agents Maggie Bell and OA Zidan trace the crime to an unlikely culprit and conduct a sting operation to prevent further attacks.

Special Agent Maggie Bell, Special Agent OA Zidan and the team investigate the murders of 18 young women with help from a survivor associated with the deceased.

Special Agents Maggie Bell and OA Zidan investigate the death of a safety inspector and its possible connection to a leak at a nuclear power plant.

After a senator’s daughter is kidnapped and held for ransom, the FBI is called in to assist with finding the child before their time limit expires. However, in order to do so, they must dig into the senator’s past for clues to who did this to his family.

Maggie and OA hunt down a ruthless group of robbers who are posing as police officers to target armored trucks.

Maggie and OA lead the search for an abducted former biological weapons chemist.

After a key witness and a U.S. marshal are ambushed and killed, Maggie and OA must track down a man who leaked the information that led to their murders.

When an illegal arms broker turned informant is assassinated, OA assumes his identity and goes undercover to stop the sale of dangerous weapons, with help from Maggie and their former FBI instructor, Rowan Quinn.

When a judge and her daughter are murdered after she sentenced a man to life in prison, Maggie and OA search for the killer behind a possible retaliation. Dana has a vested interest in this case as she has a history with the victim.

When an alt-right provocateur is murdered after giving a speech at a university in New York City, Maggie and OA investigate the school's more extreme political groups and rely on OA's sister, Amira, a student, for help.

Maggie and OA are on a mission to find a couple who are behind a spree of violent armed robberies that resulted in the death of an off-duty police officer.

After an investigative journalist is murdered, the team uncovers information linking the suspect to past cases. The victim’s death also strikes a chord with Maggie, leaving her desperate for answers in regard to a traumatic event in her personal life.

A serial bomber appears to be targeting Wall Street’s elite. Maggie and OA search for a suspect who seems dead-set on revenge, while Dana deals with Spencer Briggs, a cocky profiler brought in to consult on the case.

When the daughter of a wealthy family is kidnapped in an attempt to gain notorious internet fame, Maggie and OA discover the kidnapper’s plans go far beyond abduction in order to never be forgotten.

Maggie and Dana struggle to find justice for victims murdered by a serial killer who left a ghoulish mark on all of his victims, while the mayor limits the investigation in order to prevent economical loss.

OA and Maggie team up with members of the FBI’s Fugitives Department to track down a person wanted for murder who is also on America’s top 10 most wanted list.

An American diplomat is killed while being used as a pawn in a dangerous drug ring, and the team must work together to bring them down. Also, Jubal and OA try to help friends from their past fight off their inner demons.

When a controversial senior leader from Egypt comes to New York for a heart transplant, OA struggles to balance his personal opinion with his professional duty when he is assigned to the security detail.

After a decorated FBI agent is murdered, the team investigates and uncovers the man led a double life. Also, Maggie struggles with what information she should reveal to the agent’s widow, who is also her personal friend.

A woman with information about the death of Maggie’s husband is abducted, leading OA and the team to uncover a criminal operation larger than anyone imagined. Also, Dana puts her career in jeopardy when she stands by and allows Maggie to work on this case that has such a personal connection to her.