Premiera 1 sezonu My Next Guest Needs No Introduction with David Letterman była 12 stycznia 2018.

Former President Barack Obama reflects on political tensions and his family's life after the White House, and Dave visits Selma with Rep. John Lewis.

Premiera 2 sezonu My Next Guest Needs No Introduction with David Letterman była 31 maja 2019.

Dave welcomes Kanye West, Ellen DeGeneres, Tiffany Haddish, Lewis Hamilton and Melinda Gates for a fresh crop of funny and insightful interviews.

Premiera 3 sezonu My Next Guest Needs No Introduction with David Letterman była 20 października 2020.

Dave returns with a set of intimate, in-depth interviews featuring megastars Dave Chappelle, Kim Kardashian West, Lizzo and Robert Downey Jr.

Premiera 4 sezonu My Next Guest Needs No Introduction with David Letterman była 19 maja 2022.

Dave gets back out in the world and digs deep with guests Billie Eilish, Kevin Durant, Ryan Reynolds, Julia Louis-Dreyfus, Will Smith and Cardi B.

Premiera 5 sezonu My Next Guest Needs No Introduction with David Letterman była 11 czerwca 2024.