A 1.ª temporada de My Next Guest Needs No Introduction with David Letterman estreou a 12 janeiro 2018.

Former President Barack Obama reflects on political tensions and his family's life after the White House, and Dave visits Selma with Rep. John Lewis.

A 2.ª temporada de My Next Guest Needs No Introduction with David Letterman estreou a 31 maio 2019.

Dave welcomes Kanye West, Ellen DeGeneres, Tiffany Haddish, Lewis Hamilton and Melinda Gates for a fresh crop of funny and insightful interviews.

A 3.ª temporada de My Next Guest Needs No Introduction with David Letterman estreou a 20 outubro 2020.

Dave returns with a set of intimate, in-depth interviews featuring megastars Dave Chappelle, Kim Kardashian West, Lizzo and Robert Downey Jr.

A 4.ª temporada de My Next Guest Needs No Introduction with David Letterman estreou a 19 maio 2022.

Dave gets back out in the world and digs deep with guests Billie Eilish, Kevin Durant, Ryan Reynolds, Julia Louis-Dreyfus, Will Smith and Cardi B.

A 5.ª temporada de My Next Guest Needs No Introduction with David Letterman estreou a 11 junho 2024.