Christine's professional judgement is put to the test when a man with severe burns rejects urgent treatment. Stuart deals with a group of schoolchildren involved in a minibus accident, but inadvertently faces the wrath of one angry parent. Robert returns to A&E to show off newborn baby Harry, but ends up getting roped into dealing with two window cleaners involved in a serious accident. David continues to try to win Yvonne's affections, and Christine has a new admirer in the form of a new pediatric doctor, Andrew Argyle.

A young female who arrives in the department complaining of abdominal pain is discovered to be pregnant, and with contractions well underway, Robert faces no choice but to deliver the baby himself. Terry consoles a young woman who is admitted after cutting her wrists. The department is thrown into turmoil when a patient is admitted covered in a mystery powder, forcing Resus to be put into quarantine. Christine receives a call from a friend at City General to inform her that Issy has been involved in a serious accident.

Robert returns to work, but begins to crack under the pressure. Christine deals with a young girl who has been hit by a bus, but denies the police access to the bus driver until she can determine the identity of a mystery substance found in the girl's bloodstream. Mike angers a young mother after accusing her of abusing her six-year-old daughter. A young girl with slash wounds to her wrists is found collapsed in reception, and Stuart takes a leap into the unknown by treating a trauma patient at the scene of a hit-and-run.

Christine is made acting consultant in Robert's absence. Mike battles to save the life of a drowned child, but the father's attempts to hide the truth surrounding the boy's accident make it harder for him to administer the correct treatment. Stuart and Louise deal with a case of domestic violence involving a severed finger. David's latest attempt to bring the department up to speed with cutting-edge technology leaves him with egg on his face, and Mike is shocked by the arrival of an unwelcome visitor: his ex-wife, Stella.

Robert faces his first day back at work after Issy's death, but is confronted with a barrage of sympathy and criticism following his shaky treatment of an asthma patient. David misdiagnoses a woman suffering from abdominal pain, and when she is later found collapsed at home, Robert discovers that she is suffering from an ectopic pregnancy. David's day goes from bad to worse after he tries to make Martin see the error of his ways in spectacular fashion. Cathy finds herself being used as a go-between by Stella.

David is forced to deliver heartbreaking news to regular patient Martin, after an X-ray discovers traces of a rare form of bone cancer. However, after his grilling from Robert, David realises that it could be make or break for his career in A&E, so he decides to pull out all the stops. Stuart is forced to confront his feelings for Mandy after she is assaulted by a drug smuggler. Mike manages to clear the air with Stella, while new doctor Kate Brady surprises Louise with her skillful treatment of a patient refusing to see a female doctor.

Robert fears that he has lost his appetite for the job and turns to Christine for help. David is shocked when Martin passes away unexpectedly. Mike arranges for Stella to meet Paul and Richie for the first time in seven years. Kate struggles when faced with a patient who has suffered an ankle fracture in a car accident. Christine informs Andrew that she does not intend to pursue their relationship. Louise tackles a particularly difficult student whilst taking an educational course on the effects of road traffic accidents.

A busy Friday night shift ends in tragedy after two children involved in a car accident die shortly after their arrival at the hospital. The situation is intensified when Cathy discovers that the police officers who were first on the scene have misidentified one of the casualties. Meanwhile, Mike and Stella come head to head over his parenting skills, Robert struggles to juggle life as a single parent, Andrew offers to help David with a difficult young patient, and Louise and Stuart finally put their cards on the table.

Robert faces the challenge of his career when he leads a team to free the survivors of a horrific air crash. Among those trapped in the plane are a six-week-old baby, a seven-year-old schoolgirl, and a businesswoman suffering from an aortic rupture. While he tries to regain his passion for the job, Kate struggles to keep her emotions under control. Judy begins to question her future in A&E, and Andrew's efforts manage to impress Christine. David begins to buckle under the pressure, but manages to impress Robert.

Christine tends to a boy injured in a fight, but during examination, she discovers injuries that suggest an involvement with child prostitution. Stuart tries to help a young mother whose baby is suffering from severe diarrhea. David makes friends with a local busybody and ends up getting him volunteer work at the hospital. Mike continues to fight Stella for custody of the children. Louise tends to a young girl who has a blocked windpipe, but struggles to keep her mind on the job after discovering that she is pregnant by Stuart.

Stuart tries to prevent a patient showing signs of mental difficulty from being assessed by a psychiatrist, but his day goes from bad to worse when he receives shocking news from Louise. Mike attends court for the first day of the custody battle, but finds himself becoming an unlikely ally for Stella when the pressure of the situation begins to take its toll on Richie. Freddie panics when he learns that he is to be promoted to supervisor. Christine is forced to confront Andrew after a young mother makes a complaint about him.