Severely injured during her last battle with Zeiram, Iria finds herself more reluctant to go after Zeiram -- at least not without some advantage she might be able to use. But Kei is not so cautious. Frustrated by Iria's apparent lack of initiative, Kei decides to go after Zeiram herself, only to be stopped by Fujikuro.

Meanwhile, the Mycean council's plan to build a huge transemmbler is met with forceful opposition by the Zeiramoid clones. Zeiram has resisted every know weapon on the planet, and the only plausible solution seems to be to transport it off world, and make it someone else's problem. But Iria knows the only solution is to stop Zeiram permenantly...

Iria s'entraîne virtuellement pour faire face au Zeiram, avec l'aide de Bob. Lorsqu'elle part l'affronter à nouveau, elle est suivie par Kei qui décide de lui prêter main forte malgré son interdiction. Enfin, le combat final.

ゼイラムの正体は、グレンの変わり果てた姿だった。ゼイラムに敗れ、身も心も傷ついたイリアは、再びゼイラムと戦うことをためらう。一方、ゼイラムはビルを通信タワーと化し、仲間を呼んでいた。そこで、当局はビルごとゼイラムを宇宙に吹き飛ばす作戦に出る。そんな中、ある決意を秘めたイリアがゼイラムの前に…!!

No clímax da história, Iria e seus amigos enfrentam Zeiram em uma batalha final. Eles devem usar tudo o que aprenderam e sacrificar muito para proteger o que resta de sua realidade.