Chelsey has battled weight her whole life, avoiding Dr. Now's program since age 9. Now 25, she's ready to leave her unhealthy home and see the world. But first, she must prove she's ready to commit to the steps that will transform her future.

As identical twins, Destinee and Dynastiee, have always done everything together…including gaining weight. At over a collective 1200 lbs, they both are determined to get healthy and lose the weight with Dr. Now's help.

Destinee and Dynastiee continue their weight loss journey, but, after only one of them qualifies for surgery, the thought of moving ahead without the other is too much. They decide to do it together or not at all, knowing if one fails they both fail.

Grace has always found comfort in food; at over 600 lbs, she decides to join Dr. Now's program; that leads to the hardest decision of her life: to change her relationship with her sisters or lose the closest people in her life to get healthy.

After losing her son and her marriage, Trista turned to food, reaching over 600 lbs.; ready to heal, she seeks Dr. Now's help.

After recent deaths in his family, Caleb's struggle with his weight has gotten even worse. Now at only 20, he's already hit the 800lb mark. Caleb knows his health is reaching a breaking point soon unless he can get Dr Now's help before it's too late.

After Crystal's weight spiraled out of control, she became bedridden; she has to depend on her father and best friend to take care of her and her teenage daughter; she hopes to get Dr. Now's help, but traveling to him may not be possible for her.

Sam's dream is to do more with his wife and son, with his weight fast approaching 700 lbs, his body keeps him from doing that; determined to change, he tries to join Dr Now's program to get weight loss surgery before he loses any more time with them.

Confined to her apartment for three years, Lauren's near-death experience inspires her to lose weight. Dr. Now is her last hope, but she must overcome his program's challenges to reclaim her life and reconnect with the dreams she thought were lost.