In 1936, a young Roberto is sent to Guadalajara, where he struggles to fit in. Decades later, the now seasoned Chespirito finds himself lost without his biggest supporters at Channel 8, but memories of childhood help the comic conceive El Chavo del Ocho -- his most successful series yet.

As El Chavo gains popularity and Roberto is given more creative freedom, Channel 8's competitors vie to bring Chespirito on board. Meanwhile, success and fame cause trouble for Roberto, his team and his family, leading to the comic's most prolific -- and devastating -- era.