Tang Jiayu, a cardiac surgeon who has practiced abroad for many years, is invited by Vice President Liu Feng to return to China and lead the Heart Center at Beijing Anhe Jisheng Hospital. She becomes acquainted with Ouyang Zhenyu, the medical department director, and forms a close bond with anesthesiologist Ye Yiming. Together with her ICU team—Jiang Bailie, Long Xiangdong, Qin Dazhong, Zhou Da, and Liao Xiaobo—she treats 28 rare heart disease cases. Through their work, they successfully develop China’s first fully magnetic levitation artificial heart, making history in cardiac surgery.

心外科医生唐佳瑜的回国，她成为安和济生医院心脏中心主任并成立重病组，助推国产“全磁悬浮人工心脏”的研发应用。在多次手术中，唐佳瑜和麻醉科医生叶弈明密切配合，攻克难题。叶弈明渐渐察觉自己喜欢上了能力超群、热心于救治病患的唐佳瑜，却不得不耐心等待。过程中，唐佳瑜的国产“全磁悬浮人工心脏”应用一度遇到瓶颈，选择离开医院，去到先心病高发地区。而叶弈明也顺从自己的内心，前去寻找追随，并帮助唐佳瑜在一次次手术中找回对心外科纯粹的热爱。叶弈明等到了她的回归，在医学团队的共同努力下，最终推动国产“全磁悬浮人工心脏”进入临床