In Portsmouth's Queen Alexandra Hospital, newly-minted Matron Steph helps her team care for patients, including 79-year-old Gordon who suffered a sudden loss of consciousness at home.

Matron Hazera responds to an emergency and battles to find enough staff, while Renee treats a patient with a flare-up of ulcerative colitis and Sarah cares for a terminally ill patient.

Matron Steph trials a system to see patients quicker in ED, Renee supports a young woman with anorexia, and Rhona cares for Raymond, a patient with suspected sepsis.

Caroline treats stroke patient Maureen, Sarah helps terminally-ill cancer patient Siobhan get her pain under control, and midwives Amy and Katie deliver a perfect birth.

Matron Steph and James treat some very sick patients on the busiest shift Steph has seen in the emergency dept, while Caitlin cares for a good Samaritan in a lot of pain.

It's Halloween and Matron Hazera is having a staffing nightmare, Matron Steph meets an abusive patient in police custody, and Amy helps deliver premature identical twins via c-section.

Amy deals with a serious emergency during a birth, Caroline must rapidly help her patient breathe again, and Rhona treats Keith, who may have a life-threatening infection.

Three young newly-qualified twenty-something nurses Renee, Caitlin and Military Nurse James cope with the pressures of working for the NHS and finding a work-life balance.

Caroline treats a father of four with severe pancreatitis, Rhona restores her patient's health with a large blood transfusion, and Sarah cares for a mum with incurable stomach cancer.

James and Matron Steph have an influx of admissions in the emergency department, Matron Hazera tries to discharge patients to free up beds, and Katie stays late for a high-risk delivery.