The program follows four modern day explorers—a navigator, a wildlife expert, a survivalist, and a journalist—as they substantially retrace H.M. Stanley's famed expedition to find Dr. David Livingstone. Their route deviates somewhat from Stanley's in that it includes a treacherous crossing of the Uluguru Mountains, which Stanley circumvented.

　　距非洲东海岸二十英里，4位现代科学家(也是著名探险家)深入坦桑尼亚充满未知的内陆。他们将行驶970英里，途经最迷人的，无情的史诗般和充满危险的地形。