It's Not What You Know was a game show, hosted by Chris Tarrant, which aired on the British digital TV channel Challenge from 28 April to 6 June 2008. The show was unusual as Challenge tends to air repeats of classic game shows that were originally commissioned by other broadcasters, very rarely producing original content.

This game show also claimed to be the first ever show where people could win money by not answering any of the questions on the show correctly.