@wonder2wonder said:

In S07E21 "The Anything Can Happen Recurrence" Penny has dinner with Sheldon and afterwards she takes him to a psychic.

Sheldon's future is foretold and, as we now know, it has all come true. Everything has fallen into place.

He gave himself to the relationship and married Amy. And then he won the Nobel Prize.

Are psychics for real?

Will Sheldon become a believer now?

This a hard one…

I don’t like to use the “P” word (or the “M” word either); but as for being real...

I do believe that some people have a better “read” of people than others. Not calling it a “sixth sense”; but there is something there; otherwise profilers and “spotters” (especially the ones who work crowds), would be out of a job. While profilers are working off 'some knows'; aren’t spotters pretty much 'blindly' looking for: one-of-these-things-that’s-not-like-the-others, AND have to know it when they see/sense it.

As for Sheldon’s “P”-reading…

I don’t believe he could walk in as he did, and someone else could tell important, Sheldon-specific things about him and/or his future. These “P’s” can say whatever they please since it’s usually a one-time encounter, and it’s not as if the readee is coming back for a refund if things haven’t worked out, say, 25 years down the road.

Finally...

Sheldon is a man of science; he will never be a believer. He may not be able to explain it (yet); but, believe it...NO WAY! (On the other hand, can't help but think that "Laid-Back Sheldon" would be all over this.)