Major: Howard and Bernie "employing" Stuart to take care of Deb-Deb.

Which led to her financing the rebuilding of the comic book store. – Which led to "Gaiman" coming in and putting the place on the nerd map. - Which led to Stuart needing more help. Which led to….

Minor: Raj’s WhatEverThatWas with that older cleaning lady. Which led nowhere.

@SpecialFlowers said:

If Sheldon were to land on an iron butterfly, would it scream IN A GADDA DA VIDA?

No but I would scream if you played that.

In the garden of Eden - The Simpsons

@FormerlyKnownAs said:

Minor: Raj’s WhatEverThatWas with that older cleaning lady. Which led nowhere.

Seriously! That story flew away like a butterfly in a hurry! I was all for them working out, but now I struggle to even remember her name.

@znexyish said:

@SpecialFlowers said:

If Sheldon were to land on an iron butterfly, would it scream IN A GADDA DA VIDA?

No but I would scream if you played that.

In the garden of Eden - The Simpsons

Don't worry sweet fartgoblin, I will do no such thing.

@SpecialFlowers said:

If a butterfly were to land on Sheldon's nose, what would he do?

Just kidding. Name one portion of the storyline which if deleted would have a major effect on the overall arc. Then name one portion which if deleted would probably have little to no effect.

Mine:
Major: Howard and Raj signing Sheldon up for online dating...and the dirty sock.

Minor: The guys fighting over the Lord of the Rings ring.

Leonard dating Priya : if it never happened his relationship with Raj would be a lot better.

Also, looking back ,the Raj and Penny storyline that would have been monumental then is completely irrelevant now.

@SpecialFlowers said:

@FormerlyKnownAs said:

Minor: Raj’s WhatEverThatWas with that older cleaning lady. Which led nowhere.

Seriously! That story flew away like a butterfly in a hurry! I was all for them working out, but now I struggle to even remember her name.

That might have been the point, even if it wasn't particularly deliberate: Raj's Relationships Go Nowhere. (Recause Of Raj.)