Season 1 of Lovers premiered on November 8, 2006.

Yoon Mi-ju (Kim Jung-eun) is the daughter of a reverend, who has adopted many children and set up an orphanage. She works as a plastic surgeon in a hospital, although her dream is to open a clinic of her own. Ha Kang-jae (Lee Seo-jin) is an orphan raised by Kang Choong-shik, a gangland boss, and his trusty right hand. The two meet when Mi-ju mistakes Kang-jae for her adoptive sister's former boyfriend, who dumped her after discovering she was pregnant; as Mi-ju learns a little later, Kang-jae is actually in a relationship with Park Yu-jin (Kim Gyu-ri), Mi-ju's neighbor.

When Kang-jae is wounded by some Chinese gangsters, Mi-ju treats him and he begins to fall for her; meanwhile, Kang Se-yeon (Jung Chan), son of the boss Kang-jae works for, falls in love with Mi-ju, who his mother wants as a daughter in law because she considers her a good catch.