Tina Morris has persistent visions of her brother Randy, a soldier presumed killed in action in Vietnam. Tina seeks the help of Dr. Rhodes, who believes that Randy may still be alive, and seeking escape from a P.O.W. camp.

At a routine lecture, Dr. Rhodes is presented with a scalpel which introduces him to a complex, psychic mystery. A dying neurosurgeon believes that his daughter-in-law, Jordana, is killing him with a psychic "tumor" just like she attacked his son Joseph. In fact, Joseph has been subjected to an ongoing brutal ESP attack from an unidentified assailant - an assailant who has a familiarity with the ESP theories of Sigmund Freud.

Dr. Rhodes comes in contact with a group of five who use their psychic energy to telepathically murder. It's a race against time to see who will be stopped first-the group or Dr. Rhodes.

A young woman who has just moved into the estate of the late Frances Dahlgren imagines herself drowning in a sinking car. She also witnesses a "psychic" murderer in her bathroom, and suspects that her new home is responsible for the ESP impression. Dr. Rhodes searches for answers and discovers that there were two deaths nearby - deaths that were associated with the works of Edgar Allan Poe.

A prominent politician, Paul Crowley, has persistent waking visions in which he sees himself and a beautiful Far Eastern woman drowning in a rushing river. Crowley seeks out Dr. Rhodes, who discovers through Kirlian "aura" photography that a telepathic assassin is practicing biological imposition: an attack on Crowley's psyche that will leave the diplomat vulnerable to suggestion.

Edwin Danbury is tormented by a vision of murder. The killer is an old man long since deceased and the victims are a young couple in love.

Rhodes fulfills the death wish of an old friend by looking into his daughter's impending marriage to a man she only met a month before.

Judith Eaton believes her daughter Damaris is a witch like previous Eatons.

Dr. Rhodes' girlfriend, a fellow university professor named Diana Parker, is murdered in the park by a shadowy figure. Rhodes meets Diana's twin sister, Terri, and learns that the same killer may be stalking her. A disturbed young man, whose mother is a mind reader, is also a powerful psychic who hears the thoughts of others. He is desperate to silence Terri - a woman he believes to be the returning spirit of Diana.

Paula Norris, while riding late at night, sees a ghostly white horse. Neighbor Tuttle calls in Dr. Rhodes to investigate and ranch hand Billy watches warily. The visions continue including a ring of fire and seem to be tied to a missing girl.

A woman named Alice has a psychic impression of her sister, Monique, with whom she has been separated since childhood. Both women are in danger. Alice is dying from a failed kidney, and Monique has been captured by a Satanic cult. Dr. Rhodes hopes to find Monique, save her life, and then bring her back to the hospital, where she can donate a kidney and, in turn, save Alice.

A woman sees her recently drowned husband's image.