The setting for this human drama is a unique hospital where the doors only open at night to treat outpatients. At these late hours the staff is faced with all sorts of ailments from all sorts of patients...

The new face on the staff, Maki was trained as a pathologist but finds herself assigned to the hospital as a clinical physician. Although she's full of medical knowledge, her lack of any real experience (and her queasiness at giving shots!) keep her at arm's length from the rest of the staff. The passionate and optimistic Maki is particularly detested by Keiko, the practical and results-oriented clinical physician.

Nevertheless, Maki is determined to help her patients. Armed with her knowledge and vitality she strives to get to the bottom of the various illnesses she is faced with. As Maki grows not just as a doctor but as a human being, the rest of the staff is touched by her courage. Join the staff of Night Hospital as they rediscover "life".. --YTV Japan

夜間病院を舞台に、生身の患者と向き合う新米臨床医の奮闘ぶりを描く誠実な医療ドラマ。細胞から病因を探る病理医の森沢麻紀（仲間由紀恵）は、正義感から勤務する病院の院内感染の原因を明らかにしてしまったばっかりに、夜間病院に転属させられてしまう。病理医としては優秀だが、臨床医としての経験はまったくなかった森沢は、注射の打ち方はおろか患者の扱いも素人同然で、勤務初日から悪戦苦闘することに。

병리의인 마키는 병원내 감염의 원인이 외과부장임을 규명, 그것으로 인해 자신의 의지와는 상관없이 외과부장을 퇴임시키게 되고, 그것이 계기가 되어 마키는 야간진료전문인 나이트 하스피탈로 이동하게 된다. 이 곳에서 일어나는 에피소드를 그린 드라마