David Mitchell and Carrie Smith drive through the Nebraska plains, heading to meet Smith's boyfriend. But somewhere between home and the bar, they both disappear.

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No crime scene, no witnesses, no evidence to follow - that's exactly what investigators were facing when they tried to track down Lori Leonard. The young woman seemed to have vanished from her upstate New York home. The investigation takes police from upstate New York to New York City, throughout cyberspace, and finally -- back where they started. But could a mysterious key literally unlock the case?

After a young wife named Jami Sherer disappears without a trace, it understandably throws her family into a panic. Police investigate, and find her car abandoned in a nearby parking lot. But there's a baffling clue inside - her wedding ring has been ominously left behind. Was she murdered, kidnapped, or did she simply take off to start a new life somewhere else? It would take investigators nearly a decade to uncover the truth.

Cathy Geelan is a young wife when she disappears, leaving behind a mysterious note. All signs seem to point to suicide, but there's one problem - her body is nowhere to be found. Could she have run off and left the note as a decoy? Police search for more than a decade, and cover thousands of miles, only to be mystified time and time again.

It started out as an average night for Christie Wilson. She hit the casino for a little blackjack and had a little fun. But the way that night ended was anything but average. Christie vanished. And when police tried tracking her down, they had a mystery on their hands that, at first, looked like it'd never be solved.

One Wednesday morning Laura Mackenzie leaves home and never turns up at school. Detectives search for signs of an accident between the Mackenzie's house and the school, but there's no indication she's had car trouble. Investigators then take it up a notch and issue an All Points Bulletin for Mackenzie's car. They check accident reports, towing records and call hospitals and jails, but she's nowhere to be found. But the only thing more shocking than her vanishing act is the truth.

A man goes for a swim in the ocean, and never returns. But did he drown? The closer police look at the missing man, the more complicated this case gets. Investigators uncover secrets and follow leads from Jersey to California and finally conclude that nobody vanishes without a trace.

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Tamika Huston is a lively, ambitious young woman, with a devoted family and many friends. So everyone in her life is naturally worried when one spring day, Huston simply vanishes. Police launch a search but they can't find her anywhere. Has she taken off to start a new life somewhere else or has she met with foul play? It will take almost a year before investigators find the key that unlocks the case.

After a young woman named Brooke Henson disappears into the South Carolina night, detectives suspect she's been murdered but they can't prove it.

When wife and mother Janine Miller takes off from home one winter night, her husband immediately calls police. He says she's been drinking and shouldn't be on the road. But Officers don't locate her car that night and assume she made it home safely. It's not until a week later when Miller's mother calls police that they find out Janine never made it home that night. The investigation into her disappearance kicks off immediately; does her husband have something to do with her disappearance, was she the victim of a local serial rapist, or did she just take off on her ...

Few investigations leave as much wreckage in their wake as one in Blanchester, Ohio, a town where blood is thicker than water and loyalty runs deep. The disappearance of Carrie Culberson was so explosive it destroyed one family, and ripped a second one apart. But in the end, see how investigators pulled off a plan that no one thought possible.

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