In 2021, Alexander 'Alex' Jackson, an Eagle Scout, called 911 to report a mysterious intruder killed both his parents, Jan and Melissa, and his younger sister, Sabrina, and shot him in the foot. But as they interviewed Alex in the hospital, detectives began to suspect Jackson wasn't telling the whole truth.

In May 2018 in Westfield, MA, detective Brian Fanion, 30-year police veteran, frantically called 911 for an ambulance, saying his wife Amy had shot herself and lay dying. But when Fanion's fellow officers arrived at the house, the crime scene posed more questions than answers.

Outwardly, Mark Jensen seemed to be a mild-mannered, loving husband -- grieving over the early December 1998 suicide death of his wife, Julie, who was found by their two young sons. But when Wisconsin police found traces of antifreeze in her autopsy, they started to question what was really going on at home. They soon discover that Mark moved another woman in a month after his wife's death.

Jamaican immigrants Andreen McDonald and her husband Andre, an Air Force Reserve Major, have an autistic daughter, Alayna, and a beautiful home and successful business they built together in San Antonio, TX. When Andreen went missing, detectives uncovered turmoil within the marriage and realized this was much more than a missing persons case.

When interior designer Jade Janks discovered her beloved stepfather, butterfly conservationist Thomas Merriman, had secretly downloaded nude photos of her onto his computer, she set out to put an end to the abuse. A 911 call was received from Jade's friend, which prompted a welfare check; Tom was missing.

Disbarred attorney Richard Merritt prepared for a last home-cooked meal with his mother before he was set to report to jail for embezzlement. But he didn't show up on time and his ankle monitor had been cut. The next day, relatives found his mother stabbed to death in the basement of her home. Eight months later, Merritt was found in Nashville, TN, under an assumed name. When the murder trial started four years later, Merritt claimed an intruder had attacked them both and he had fled for his life.

James Ray III, a prominent attorney, former NYC police officer, and former U.S. Marine, lived in an upscale Upper Montclair, NJ home with his girlfriend Angela Bledsoe, a successful businesswoman, and their young daughter. After a weekend away, Angela didn't show up for an appointment; Ray dropped their daughter off with his brother who found a note in her suitcase and promptly called 911. The police are dispatched to their house and find Angela dead on the kitchen floor; Ray and his BMW are nowhere to be found.

When devoted single mom Becky Bliefnick fails to pick up her boys from school in Quincy, IL, her father went to check on her and found her dead in the bathroom. Detectives learn she was going through a contentious divorce and dating someone new; they find a major clue in an unlikely place–on an episode of the game show "Family Feud."

When single mom Sadie Beacham didn't receive a good night call from her boyfriend, single father Rosalio Gutierrez Jr., she was alarmed and went to his house to find his screen door wide open and blood all over the floor. Wisconsin detectives could not locate his body but DNA evidence pointed to someone Sadie knew well.

In Dallas, TX, middle-aged couple Jamie and Jennifer Faith were on a routine early morning stroll with their dog when a man attacked out of nowhere, injuring Jennifer, duct taping her hands, and fatally shooting her husband, Jamie. What was behind the mystery attack?

Around 5:40 am on July 31, 2022 In Strongsville, OH, a car with three teenage friends inside - Mackenzie Shirilla (driver), Dominic Russo (front passenger), and Davion Flanagan (backseat) - careens into a building's brick wall at 100 miles an hour, killing two of them instantly and injuring the third.