Denise Chamian, a native of Los Angeles, began her career in the entertainment industry at a small theatrical agency. While there, she discovered her passion for casting and transitioned into the field through mentorships with renowned casting directors Janet Hirshenson and Jane Jenkins.

Over nearly four decades, Chamian has forged a reputation as one of Hollywood's top casting directors. Her credits span a diverse range of major motion pictures, including Saving Private Ryan, Minority Report, Big Fish, Pirates of the Caribbean sequels, and modern blockbusters such as Transformers, The Lone Ranger, Red Sparrow, the Maze Runner franchise, Bumblebee, Call of the Wild, Top Gun: Maverick, and Elvis. Her work in film has generated over $11.6 billion at the global box office, ranking her among the top ten highest-grossing casting directors worldwide.

She won the 1999 Artios Award for Best Casting in a Feature Film or Drama and has received numerous nominations since then. In 2023, she co-won the BAFTA Film Award for Best Casting for Elvis alongside Nikki Barrett. Her accolades also span Emmy nominations and nominations for the Casting Society of America (Artios Awards).

Chamian runs her own casting company in Los Angeles, where she balances large studio blockbusters with smaller, independent productions. Known for her openness to new talent, she began the global casting search for Elvis by sifting through hundreds of auditions, ultimately casting Austin Butler.

Although she did not attend college, Chamian thrives on the creative and business aspects of casting. She champions the importance of recognising casting's contribution to storytelling. She highlights how new technologies—such as self-taped auditions—have expanded access for actors. She advises actors to come prepared and grounded, emphasising the importance of being off-book and open to direction.