After a naive Midwestern girl's big city dreams are dashed her first week in New York, she finds herself living with her worst nightmare in this hilarious, contemporary comedy about a female odd couple who are surrounded by an outrageous cast of characters.

Elena "Yo-Yo" Rodriguez, an Inhuman with the ability to move at super-speed, is required to sign the Sokovia Accords. However, the restrictions of the Accords are in direct conflict with a personal mission she's desperate to fulfill, one that will test her abilities and will include tense encounters with S.H.I.E.L.D. team members.

New interns' tackle their first day as surgeons at Grey Sloan Memorial under the watchful and stern eye of Chief Bailey.