"Al rojo vivo" is a program on laSexta focused on the analysis and debate of national and international political current affairs. The format is hosted and directed by Antonio García Ferreras and produced by the News Services of laSexta.

Mankind is suffering the biggest exodus in history. Three billion people from the future have traveled to the present to escape from an imminent global disaster. All the refugees must obey to rules: they must not talk about the future and they must not contact their families. The arrival of the refugees take everyone by surprise, including the Cruz family. The series centers on their story, the story of Samuel, Emma, and little Ani. The shift in their existence after the arrival of the mysterious refugee, Alex, who has an incredible mission that will change their lives, and in order to accomplish his mission, he will not hesitate to do whatever there is to be done--including breaking the rules.

Caiga Quien Caiga, also known as CQC, is an Argentine television show. Under the format of the production company Cuatro Cabezas, CQC has also been adapted in Spain, France, Chile, Italy, Brazil, Portugal and briefly in Israel and the Netherlands.

It won an International Emmy for Best Non-Scripted Entertainment in 2010.

El Intermedio is a satirical news program hosted by Spanish comedian El Gran Wyoming. It is aired in access prime-time, from 9.30pm, on Spain's sixth nationwide channel laSexta.

The writers are Alberto López, Alberto González Vázquez, Lola Zambade, Eva Nuño Gómez, Nuria Dominguez, Diego Solanas, Eduardo García Eyo, Sergio Sarria Ruiz, Juan José López and Miguel Ángel Hernández. Alberto González Vázquez is also the author of the popular segment videos manipulados.

Based on Ramsay's Kitchen Nightmares, Pesadilla en la cocina folllows Madrid-born chef Alberto Chicote across the Spanish geography to try to save restaurants on the verge of bankruptcy. Let the chefs, waiters and owners who do not manage their business to the liking of the great Alberto Chicote tremble.

Spanish game show based on the original British format of "Who Wants to Be a Millionaire?".