It's Christmas Day in the home of Granny, and her pet cat Sylvester delights at chasing her new Tweety Bird and takes fright at the bulldog unwrapped from under the tree.
An elderly mouse tells the bedtime story of Little Red Riding Hood to her grandson, who visualizes the tale in cat-and-mouse terms, with himself as Red and Sylvester as the Big Bad Wolf.
Sylvester Cat finds that his people have gone on vacation and left him alone in a locked house with a large stash of canned food in a cupboard. Sylvester needs a can opener, or he'll starve. And a pesky mouse has the only can opener in the house and torments Sylvester into trying more and more desperate measures to obtain it.
Speedy comes to the aid of a group of mice trying to get the cheese from a factory guarded by Sylvester.
Sylvester Cat tries to catch Tweety Bird, who is up in a tree in the middle of the city dog pound.
A spurned love bird tries to get Sylvester to put him out of his misery.
Tweety Bird goes to the beach with Granny, and Sylvester tries once again to catch him.
Porky puts his cats out in the snow, but then they put him out and have a party. Expelling them again, Porky goes to bed, only to be terrorized by the felines' mock Martian invasion.
Porky Pig and Sylvester the Cat spend the night in an old dark house, whose horrors only Sylvester sees.
In this spoof of Alcoholics Anonymous, pussycats are cast as bird-eating addicts and go through the 12-step process to deal with their addiction. Sylvester, who could never quite get the best of the object of his desire, Tweety Bird, joins and resolves to quit chasing and eating the canary.
Sylvester Cat spots Tweety Bird in a San Francisco apartment and tries to gain access but cannot make it past Granny or the cat-hating desk clerk.
Thomas the cat finds Tweetie in the snow, warming himself by a cigar butt. Thomas's mistress rescues the little yellow bird before her cat can devour him, but Thomas doesn't give up.
Sylvester's carnivorous pursuit of Tweety Bird continues, winding up the cat's spirit in Hell, where he meets a satanic bulldog.
Daffy tries to sell movie studio head J.L. his script for a swashbuckler set in Merry Olde England, a plot involving a maiden in distress, a scheming Chamberlain, an evil Grand Duke and a dashing masked hero (to be played by Daffy, of course).
A rough and tough bulldog named Spike sets out with his admirer, a small dog named Chester, to rough up a cat. They encounter Sylvester and chase him into a junkyard, where a black panther that escaped from a zoo just happens to be hiding out. Every time Spike goes into the junkyard to thrash Sylvester, he is clawed into pieces by the panther, which he, in a dark maze of crates, thinks is Sylvester. Chester has no problem pummelling Sylvester before Spike's eyes, which convinces Spike that Chester must be tougher than him.
Tweety Bird is washing in a bird bath in a city park when Sylvester Cat interrupts him. Sylvester chases Tweety, and Tweety takes refuge near a feisty nanny and her toddler. Sylvester dresses as the toddler to try to grab Tweety but is stopped and spanked. Tweety flies to a building ledge, and Sylvester unsuccessfully uses chewing gum to try to reach him. Next, Sylvester angers a bulldog, who chases him away.
Sylvester the cat imitates the Pied Piper of Hamelin to lure a group of mice into a jug that he seals with a cork. But Speedy Gonzales won't be hypnotized by Sylvester's flute and gradually rescues his friends from Sylvester's clutches.
Sylvester Cat and his orange feline friend, Sam, are rummaging through trash cans for food in the evening on a waterfront when they spot a mouse. They agree to share the little rodent for breakfast the next morning, while during the night each tries to snag the mouse for himself.
Sylvester sings opera and popular tunes while standing on a back alley fence; Elmer, who wants to sleep, tries to thwart him.