Brother and sister Ty and Abby Archer work for the government's Grossology department as they solve crimes and save their world from disgusting supervillains.

This animated series, based on the series of books by Knife and Packer, follows the adventures of the eponymous hero and his two creators, best friends Gene and Gerald, as they report on all things grotesque on their TV show Gross-Out TV, and face off against the evil Dr. Dirk Spamflex and his dastardly machinations.