A British medical doctor fights a cholera outbreak in a small Chinese village, while also being trapped at home in a loveless marriage to an unfaithful wife.

A squad of police cars responding to an emergency call races through the streets of Atlanta. Upon arrival at the crime scene, they see complete desolation. Dead bodies are everywhere. And they apparently just missed the killer, though one of his victims, the head of New York's Russian mafia, survived. The family's crime operation then comes to London, but unknown to them, the assassin has also moved there and is working for the police as a pathologist. And while the family is still hunting the assassin, he is on his own mission of revenge.

A writer of graphic novels who is given the task of writing a biography on the foremost occultist Aleister Crowley. Things start to go wrong when he discovers a rune inserted in Crowley's diary when visiting New Orleans.