Tom Kane cements his mayoral legacy with a lavish ceremony celebrating the groundbreaking of the new modernized O'Hare terminals. Now Kane looks to the future, setting his sights on reviving a subsidized housing project. While his political future seems bright, Kane continues to battle for control over his disease.

Kane uses personal tragedy to further his agenda, poaches his nemesis's aide, Mona, and hires ambitious newcomer Ian - but will they be enough to fill the void that Stone left behind?

Kane attempts to clean house and deep-sixes longtime political cronies, while at home, Meredith and Emma want no part of a family reunion with him.

Kane's corruption sweep threatens his political hold over the City Council. His mental symptoms begin to spiral out of control - Kane can no longer tell what is a hallucination and what is reality.

Kane's moves with the housing project escalate tensions from unrest to rioting and looting. As Chicago burns, Kane secretly seeks treatment at an alternative clinic, where his past haunts him.

Kane's alternative treatment seems to have worked and he is back in control of his city. Now he must remedy his public perception, even if it means making an old friend collateral damage.

In order to keep his grip on Chicago, Kane finds he has no choice but to work with Alderman Ross.

Chicago's bankruptcy crisis means a loss of power for Kane as emergency measures are put in place, but threats by his enemies to expose him could be of even greater concern.

Miller publishes a story that could destroy Kane, but Kane's biggest threat is Kitty's alliance with Doyle. As Meredith forms a new relationship, Kane goes to the greatest lengths yet to stay on top.