Known for her quick smile and lightning speed on the soccer field, 17-year-old Brittanee Drexel from Rochester, N.Y., slipped off to spring break vacation in Myrtle Beach, S.C., without the consent or knowledge of her parents. On April 25, 2009, the night before she was supposed to come home, Drexel disappears. Video surveillance shows Drexel exiting a friend's hotel and her last known communication is a text to her boyfriend. But when police track her cell phone to an isolated rural area known for alligators and swamps, her family fears the worst.

After spending the day with students on October 24, 2005, 30-year-old high school teacher and former beauty queen Tara Grinstead vanishes from her home in Ocilla, Ga. To investigators, it first appears that Grinstead left with someone willingly - until they discover a latex glove in her front yard containing male DNA and indicating foul play.

Police receive a tip 6 years after a 28 year old woman disappears connecting an old colleague to it and another women's murder.

33-year-old Tanya Rider goes missing after her overnight shift at a grocery store in Bellevue, Wash. When her husband Tom contacts 911, emergency officials refuse to file a missing persons report because they think Rider may have left on her own. Tom must battle to get authorities to start a proper investigation, and when they finally do, detectives suspect he's involved.

Marina resort owners are no where to be found after meeting with their accountant when they discover money missing.

Man vanishes from his new apartment and his parents life is turned upside down only to find he has been guarding a dark secret.

After six months in the Mojave Desert in 2004, following the custody loss of her children in TX, 30-year-old April Pitzer is ready to come clean and return home. But when her past comes back to haunt her, the mother of two is nowhere to be found.

When a 45-year-old CFO's SUV is found abandoned in a state park a day after he leaves his Little Rock home for work one Monday morning, friends and family speculate whether troubles at work over an impending deal are tied to his disappearance.

While shopping for land in Oklahoma, Bobby and Sherilyn Jamison and their six-year-old daughter Madyson vanish. Mystified investigators uncover a series of disconnected leads pointing to drugs, family dysfunction, and even supernatural beliefs.

Tim Carney vanishes one morning on his way to morning prayers at his church. After Tim's car turns up by the airport and his bank account is nearly emptied, the Carneys believe he may have fled the church and its strict lifestyle, prompting a search.

When thirty-three year-old roofer, Jeramy Burt's car is found torched in a remote desert valley in southern Idaho, three months after he goes missing, text messages sent to his ex-wife about wanting to start a new life are now questionable.

When 17-year-old Kara Kopetsky doesn't come home from school one day, her family panics. Foul play is suspected and a series of unsettling clues surface. But the leads grow cold until a month later when another local teenage girl goes missing.