Customs and Border Protection officers found 4 kilos of cocaine in the suitcase of a passenger arriving from Guyana. Homeland Security investigators are interrogating him and trying to find out who he brought the drugs for. Later, a young man from the Dominican Republic is stopped and questioned for his nervous behavior, while a man from Bangladesh comes forward with a confusing story. Meanwhile, investigative units scan luggage on overnight flights with X-ray machines and dogs in search of illegal substances, while postal packages are screened for contraband.

Two passengers arriving from Guyana will also be noticed by customs. Cocaine was found in the converted suitcase of one of them, while the other was unable to give a meaningful answer when stopped and was taken in for questioning to find out the reason for his confusion. During the passport control, a suspicious stamp of a passenger arriving from Paraguay is noticed by the inspectors. A passenger from Jamaica is found to have cocaine in his shoe sole and is interrogated by a special agent for internal security. Meanwhile, postal packages are screened for illicit substances and an agricultural specialist searches passengers' baggage for illicit foodstuffs.

CBP's target team discovers a package containing engine pistons. When the weights of each piston begin to differ drastically, the officers decide to drill for drugs, leading them to a heroin trafficker in D.C.

After CBP officers search bags, they discover cocaine in the lining of some coats. In the mail room, Officer Boris identifies a package containing a photo album and half a pound of heroin worth around $13,000.