In the first episode of Game Center CX, Arino visits Taito to learn it's history and play one of it's most difficult and cruel games Takeshi no Chousenjou. Upon first entering Taito he marvels at the Space Invaders machine. Tomohiro Nishikado, the creator of Space Invaders comes and discusses with Arino the history and impact of the game and they challenge one another to a game. After this Arino meets Akira Saito to discuss the Densha de GO! series. As the tour continues he finds out nobody from the original development team of Takeshi no Chousenjou is left so he meets Tetsuo Egawa instead to discuss it. To find out more about the legendary game he talks to Kazuhiro Hayashi who presents Arino with guidebooks for the game. Finally we see Arino tackle Takeshi no Chousenjou which includes various hilarious snippits of him getting frustrated at the game's bizarre challenges such as singing karaoke, and waiting one hour without pushing anything.

Arino visits the headquarters of Koei to speak with the two men behind the Dynasty Warriors and Nobunaga’s Ambition series of games. He then speaks to a PR representative about another of their popular series, Angelique before taking on the latest addition to the dating sim series, Angelique Trois. It's quite a change of pace from Arino's last challenge but that may work against him as he relaxes and opens his heart to his many suitors. Contains interviews with Kou Shibusawa, Takazumi Tomoike, and Tomomi Matsushita.

Arino enters the Capcom building in Osaka and meets his first interviewee: Keiji Inafune, the creator of Mega Man and Onimusha, among others. Then he interviews Hiroyuki Kobayash and Atsushi Inaba. Lastly, Arino takes a seat in the Fuji Multi-Theater for some extra-special playtime with Tekki (Steel Battalion).

This episode centers on Hudson, featuring some of their hit games in the collection. The Challenge centers on Star Force where Arino must get the 50,000 bonus from Rarios; Takahashi Meiijin shows up to help Arino as well. Contains interviews with Akira Sakuma and Eiji Shio.

During this episode Arino's challenge is to defeat Astro SASA! Will he surpass this challenge or give in? Contains an interview with Hiroyuki Sonobe.

Can Arino blast every enemy in the arcade classic Galaga's first bonus stage?! Featuring interviews with Iwatani Toru (Pac-Man) and Endo Masanobu (Xevious, Tower of Druaga).

Arino must trap six aliens at once behind one door in the Famicom classic Door Door. Featuring the game's creator, and Chunsoft founder Nakamura Koichi as well as an interview with Shinichiro Tomie.

In this episode Arino is faced with a 3 round Konami challenge. He must go through challenges on the games Yie Ar Kung-Fu, Gradius, & Konami Hyper Olympics. Features extensive interviews with developers (Shingo Takatsuka, Akira Yamaoka, and Toshiki Yamamura) behind the PES and Silent Hill series.

Arino is faced with the difficult challenge of beating Super Mario Brothers 2 for the Famicom Disk System. He first practices is skills with the original Super Mario Brothers before moving onto Super Mario Brothers 2; will he be able to beat the game? Or will he be defeated by one of Nintendo's own? Contains interview with Yoshio Sakamoto.

Previously bested by Super Mario Bros 2 (SMB: The Lost Levels), Arino vows revenge. Staff involved in the Pokemon games are interviewed including Satoshi Tajiri.