Three test subjects of an elaborate experiment start experiencing strange symptoms and turn to geneticist Dr. Alex Sarkov for help.

In hopes of finding Sarkov, the Imperfects look for another Wellness Program participant while dealing with the fallout from their new powers.

The search for Sarkov leads Juan, Abbi and Tilda into a seriously messed up situation. A mysterious woman begins to zero in on her targets.

While Juan reconnects with family, Abbi and Tilda meet another test subject with powers of his own. Investigators start to hunt for the Imperfects.

Burke and Sarkov begin work on a cure, with Burke as the test subject. When government agents track them down, the group rallies to fend them off.

Abbi, Juan and Tilda investigate an attack after a mutant strikes. Sarkov inches closer to a cure, while Burke has a breakthrough.

In need of nanobots to distribute his cure, Sarkov sends the team on a mission to Idaho. Burke and Finch team up to stay one step ahead of Dr. Crain.

After receiving bad news from home, Abbi attempts to replicate the cure. Juan attends a party. Tilda tries to warn Sarkov of the risks of using nanobots.

Abbi and Tilda band together with an unexpected ally to go after Sarkov, who has big plans for Juan. New revelations bring new challenges for the group.