At the request of General Fasoose, MacGruber is released from prison for one last suicide mission.

Captured by his enemy Brigadier Commander Enos Queeth, MacGruber must make an escape or be killed.

MacGruber races to retrieve the deadly chemical weapon "Brimstone" before Queeth can get to it.

The gang goes undercover at a gala in Miami to stop Queeth from synthesizing "Brimstone."

With the team in shambles, MacGruber attacks Queeth's compound to get revenge.

The plan Queeth set into motion is still alive, and MacGruber must find out who is behind the attacks.

With the team back together, all roads lead to the mysterious “Havencroft.”