The Miracle Mets go from perennial cellar-dwellers to top of the National League. The majors add teams to Seattle, Kansas City, San Diego, and Montreal, the first Canadian baseball team. They also realign into East and West, and the League Championship Series is born. The Mets meet the Orioles in the World Series.

A year after the big move to LA and a second-to-last place finish, the Los Angeles Dodgers try to return to prominence. Meanwhile, in the American League, the Chicago White Sox wish to finally overcome the untouchable Yankees. The Dodgers meet the White Sox in the World Series.

The baseball season is played amongst the backdrop of social unrest. While the Summer of Love begins in San Francisco, the Detroit Tigers deal with a summer of racial conflict. The Boston Red Sox try to make their impossible dream come alive. The Cardinals meet the Red Sox in the World Series.

The St. Louis Cardinals make a run for the title with the help of sluggers Larry Walker and Albert Pujols. The Minnesota Twins see the rise of ace pitcher Johan Santana. The Boston Red Sox attempt to shake off the memories of their defeat the previous year at the hands of the Aaron Boone and the New York Yankees. They get their chance when the two get a rematch, resulting in the greatest comeback in the history of the game. The Red Sox meet the Cardinals in the World Series.

The Florida Marlins try to recapture the glory of their championship season, becoming one of the eight teams in the National League contending for the wild card. The rivalry between the New York Yankees and the Boston Red Sox heats up after the Yankees win the fight for Cuban defector José Contreras. The two teams get a chance to duke it out on the field when they meet in the ALCS. Meanwhile, in the NLCS, the Chicago Cubs try to triumph against their past and win a pennant. The Marlins meet the Yankees in the World Series.

The Minnesota Twins win their second AL pennant since the move to Minnesota. The first World Series to be played indoors introduced the St. Louis Cardinals to the dome field advantage. The Twins meet the Cardinals in the World Series.