Dusty Crum and his team of snake hunters devise a plan to stop Florida’s invasive pythons from spreading north and becoming a national emergency.

While Dusty and the team stave off the spreading invasion by creating a “tourniquet” at the Stormwater Treatment Areas, Gary lobbies to go down south and hunt for a new record-breaking snake.

Dusty and the team must capture a giant calf-eating snake and venture into an abandoned factory to save upper Florida from invasive pythons

Dusty and team trek deep into an abandoned housing development where pythons are killing off wildlife; when Dusty injures his foot on the hunt and turns back alone, he comes face to face with a monster snake.

To prevent the snakes from destroying southern Florida, the team targets islands off of Snake Bight Bay; Brittany plans her own hunt for the first time, but it may be more than she bargained for.

Dropping temperatures force Dusty and the team to change hunting strategies, but a run-in with his old rival Cowboy throws the team off the trail.

Winter's arrival drives mating pythons underground, forcing the team to navigate a network of dangerous tunnels.