Maria is excited about a new clinical trial, but her children are alarmed when radiation treatments to her brain begin affecting her physical and mental capacities. With a diagnosis of pancreatic cancer, Lenore, herself a death and dying psychotherapist, prepares to say goodbye to her sons, grandchildren, and husband of 53 years.

Little struggles in her new role as primary caretaker of her mom and her two younger siblings. Meanwhile, a man in the advanced stages of ALS seeks redemption for past transgressions and a reunion with his mother and two sons he’s never known.

Maria's family is pushed to its breaking point with a surprise visit from Jim, her ex and the father of Julia and Andrew. As a public health advocate who has devoted her career to preventing cancer, it feels like the ultimate irony for Dr. Toni Yancey to receive a diagnosis of lung cancer. With her partner by her side, Toni reconciles that she won¿t have more time to help others or be an example to their young granddaughter.

With her two teenagers now in foster care and their custody still unresolved, Maria heads to court with Little, determined to prevail in the final showdown with the kids' father. Forced to move cross-country due to metastatic cancer, Laura and daughter Lisa turn it into a big road trip in an effort to have as much fun as possible with Laura's remaining time. Brad is resigned to death, but his loving wife Verda of 49 years is not ready and left speechless when his final wish is revealed.

Will Little finally get permanent custody of her siblings and bring them home from foster care after Maria's death? Nineteen year-old Nicolle isn't ready to stop fighting in her battle against stage IV melanoma; however, frequent hospitalizations have her extended family fearful they won't be able to honor her wishes. Season finale.