In 2014, Malaysia Airlines flight MH370 vanishes. Rescue crews search its last known position but find nothing. The fate of the flight remains a mystery. Theories abound but facts are few. Did it crash and if so, why can't we find the wreckage?

Atlantis is one of the most famous disappearances of all time. After thousands of years, state-of-the-art technology might finally be able to crack this ancient mystery. And after nine hikers die in a gruesome cold case, new science provides a hot lead.

After a huge cargo ship suddenly vanishes with 27 crew members on board, new evidence suggests the culprit may be a mythical rogue wave. And could recently discovered evidence prove the existence of a ghost ship in the Californian desert?

In 1962, three convicts attempt the impossible and escape from Alcatraz prison. Officials believe the men drowned, but a new scientific experiment suggests they made it to shore.

The Roanoke colony vanished without a trace, and centuries later it remains one of history's greatest unsolved mysteries. But new evidence might at last reveal its fate. After a man is swallowed by the earth, experts wonder if a sinkhole is to blame.

After five planes vanish in the Bermuda Triangle, new science suggests a strange geological force is responsible. Today, satellites are revealing lost tribes living in the Amazon jungle, but some civilizations remain missing, stumping experts.

In 2009, an Air France flight went missing and investigators discover this tragedy could happen again. After a huge area of Siberian forest is destroyed, investigators race to find the culprit. New evidence may finally solve this century-old mystery.