Founder Rob and vet Moose investigate a claim of dogfighting; members Brian and Face set out to help an aggressive dog on a chain; rescuer Dori helps a homeless vet and his cats.

Rob and Dori hope to rescue a dog from its chain; Moose and Elle confront a man accused of dog abuse; Brian and Amanda meet a homeless veteran and his two dogs.

Rob & Elle investigate a claim of dogs on a hot roof; Brian & Face help a woman whose neighbor is provoking her dog; Dori & Moose meet a cat hoarder who is more than she seems.

Dori revisits homeless vet George to clean up his campsite, finding a surprise; Marceline & Elle investigate a claim of starving horses; Rob & Bill help cats caught in a heated conflict.

The Guardians of Rescue head to flood-stricken Louisiana to rescue the loved ones left behind - people's animals. In the midst of natural disaster, the Guardians face their biggest rescue challenges yet (Season Finale).