One day, Natsume finds a yokai named Kagejawan running around near his home, which he soon learns means disaster is about to strike.

Natsume is accosted by a spirit who asks for her brother's name back. She says that both of them have come from the village of floating spring, a paradise sealed off from the land of men. Meanwhile, the local Youkai are happy that the local priest is no longer in his temple. Natsume worries for his friend Tanuma, the priest's son, but isn't sure what to say...

Natsume is approached by someone he knew from elementary school. He wants nothing to do with them, but they threaten to reveal his secret: that he can see Youkai, if he doesn't come along with them. He reluctantly goes with them, and is taken to meet a strange girl...

Midterms are over, and Natsume leaves on a trip with Nishimura, Kitamoto, and Sasada. He realizes that the scenery he's viewing from the train is from one of the places he grew up in, when he was passed around from one family to the next. He'd thought he didn't have any good memories of the time, but then he remembers what happened when he lived there...

There is something killing Youkai and draining them of their blood. Natsume can't help but investigate and runs into old friends.

Natsume finds out who's been stealing the youkai blood: the exorcist Matoba Seiji. He investigates with the help of Natori, but is captured by Matoba's servant youkai. Matoba is willing to sacrifice any number of youkai for his own ambitions. He tells Natsume why he's gathering blood: to release the seal on a powerful youkai. Natsume learns that there are people who treat Youkai in a totally different way than he or even Natori.

Natsume is invited to go to a pottery classroom with Shigeru. It's being held in an inn where he once stayed. When he goes there, he meets an old friend: the young fox child he once saved.

Without Sensei to protect him, Natsume has to remain constantly on guard. But the pressure of keeping secrets from his friends is causing Natsume to break.

After a brief incident in the forest, Tanuma has become distant to Natsume like he is avoiding something. In the meantime, there is something breaking glass around the school.

Tanuma is experiencing how Natsume lives every day. While Natsume and the youkai gain an understanding.

A youkai from Natsume past has found him and memories of living with relatives before the Fujiwaras are explored.

The youkai hold a party to celebrate Natsume. Things get out of hand when they ask Natsume for a human game, and he suggests Shadow Tag. When Nyanko-sensei becomes "it", he starts stomping youkai left and right. And then Misuzu-sama, the 100 foot tall youkai, shows up...