Pagkatapos ng dalawang napakahirap na misyon, ang Guardians of the Globe ay nahihirapang magkaisa. Samantalang sinusubkan ni Mark na pagbalansehin ang tungkulin niya bilang bayani, mga personal na relasyon, at ang kinabukasan niya bilang estudyante sa kolehiyo.

Habang sinusubukan ni Mark na isalba ang personal niyang buhay, may darating na bagong kontrabida, na magiging pinakamatinding hamon para kay Invincible. Hinaharap ni Donald sa nakaraan niya.

Mark Grayson is back and stronger than ever – with new enemies out for blood and old villains out for revenge.

Mark takes a stand, unaware of the ramifications for his family, the GDA, and even the Guardians. Cecil remembers his past and Eve makes an important decision.

A powerful new figure challenges Mark's idea of what's right and what's wrong. Rae approaches Rex with a big life decision.

Earth's greatest heroes join forces to fight an unimaginable threat.