When the mother of a patient dying of a rare brain disease holds a hospital hostage in an attempt to get her daughter a lifesaving surgery, McCall races to resolve the situation peacefully while dealing with pushback from government forces.

When a man claiming to have lost his memory wakes up behind a dumpster with a gun in his hand, McCall and the team follow a trail of clues to help uncover his whereabouts the night before.

After a high-powered real estate developer is killed by a moving subway train, his widow hires McCall to investigate his death. Meanwhile, Aunt Vi and Dee visit an old neighbor living in a nursing home who may need their help.

After Mel is reunited with her brother, McCall helps him blow the whistle on his former unit's unethical practices before it's too late. Aunt Vi and Trish's relationship becomes fractured by Vi's need to protect McCall's true identity.

Dee asks McCall to help find her transgender friend when the teen goes missing. Meanwhile, Dante is surprised when Big Ben's parole officer approaches him to chaperone his father for an out-of-state trip.