The year is 2010 AD. Romani Archaman has been posted to Chaldea, where he becomes the primary doctor for a young girl. Mash Kyrielight, Chaldea's second successful summoning experiment, is interested in the word "Senpai."

Fujimaru and entourage, in order to rescue the people left behind in the fortress city of Nippur after communications were severed, begin their battle against the fake Enkidu who had been awaiting them. With Fou's help, they were somehow managing to keep things even, but in the midst of battle, the Goddess of the Demonic Beasts finally appears. Even Merlin is at his wit's end facing her overwhelming power. Meanwhile, Ushiwakamaru and Leonidas I engage in a spectacular battle, standing up defiant against the Goddess of the Demonic Beasts. In order to break through the situation where it is hard to deliver a wounding blow, the two Servants unleash their Noble Phantasms with desperate resolve.

Fujimaru and company finally succeed in defeating Beast II, though this victory was won with many sacrifices. The entire group is wounded and battle-weary, and as they take stock of the aftermath, they see that Uruk itself is on the verge of collapse. What will the end of their journey bring them?