On 8 January 2003, Air Midwest Flight 5481 crashes into an aircraft hangar at Charlotte/Douglas International Airport seconds after takeoff on a flight to Greenville. All 21 people on board die, and one person on the ground is injured. Investigation showed that the pilots' controls had been improperly adjusted during maintenance, and that the aircraft was overloaded due to outdated formula for calculation of passenger weights.

A Lockheed L-1011 Tristar operating Eastern Airlines Flight 401 to Miami International Airport crashes in the Everglades because the crew is distracted by a faulty landing gear indicator light and accidentally disengage the autopilot. 101 people die.

On September 8, 1989, Partnair Flight 94, a charter from Oslo to Hamburg, suddenly begins to dive from 22 thousand feet. The aging propeller plane eventually crashes into the sea, killing all 55 people on board.

On 1 February 1991, USAir Flight 1493 collides with a waiting SkyWest Airlines aircraft on the runway, killing 34 people. An air traffic controller mistakenly assigned the inbound Flight 1493 to land on a runway where SkyWest Flight 5569 was waiting to take off.

On 27 December 1991, Scandinavian Airlines Flight 751 crash-lands without loss of life in Gottröra moments after taking off due to both engines failing. Clear ice from the tops of the wings had been sucked into both engines, causing internal damage. An automatic system (of which the pilots were unaware) to increase the engines' thrust contributed to their failure.

On 11 September 1991, Continental Express Flight 2574 is nearing the end of its intra-state flight from Laredo, Texas, to Houston. As the pilots are preparing to land, the aircraft tips into a dive and falls out of the sky as the left wing tears apart. All 14 people on board die. Improper maintenance caused a section of the horizontal stabilizer to break loose during flight, after which the pilots had no control.

On 24 May 1988, TACA Airlines Flight 110, a near-new Boeing 737, flies through a thunderstorm and suffers a dual engine flameout. The captain, Carlos Dardano, manages to make a successful deadstick landing on a narrow grass levee in the Michoud area of eastern New Orleans.

On 11 May 1996, 10 minutes after takeoff, ValuJet Flight 592 crashes into the Florida Everglades, killing all 110 people on board. The cause was an in-flight fire which was started by the accidental triggering of a chemical oxygen generator improperly shipped as cargo.

On 10 April 2010, a Polish Air Force VIP aircraft carrying the President of Poland Lech Kaczyński, his wife Maria Kaczyńska and other top officials, crashes short of the runway in a wooded area while on final approach to Smolensk North Airport in heavy fog and low visibility. All 96 passengers and crew members on board are killed.

On 6 June 1971, Hughes Airwest Flight 706 collides with a United States Marine Corps (USMC) jet fighter above the San Gabriel Mountains. A total of 50 people from the two aircraft are killed, with the backseat crewman of the USMC aircraft the only survivor.

On 10 January 2000, Crossair Flight 498 crashes just two minutes after takeoff from Zurich, Switzerland, while heading for Dresden, Germany, killing all 10 people on board. The investigation found that the pilots had suffered spatial disorientation.

On 9 August 2007, Air Moorea Flight 1121 crashes shortly after taking off from Moorea Airport in French Polynesia. All 19 passengers and the pilot died. The cause was a badly worn and partly broken elevator control cable failing completely in flight. It was put under more strain than it could handle as the force on the elevators changed with flap retraction. The situation was likely aggravated by the aircraft being repeatedly buffeted by jet exhaust while parked, stressing the cables further.