On 20 December 1995, American Airlines Flight 965 is en route to Cali, Colombia. The crew members are asked if they would like to perform a straight-in approach to Cali. The pilots accept the offer, but as they are making the necessary changes, they inadvertently remove the waypoints from the flight plan in their flight management system (FMS), causing them to become unsure of their exact position. The crew members' mistakes leads them to fly the aircraft into a 9,000 foot mountain near Buga. Only four passengers and a dog survive.

On 6 February 1996, Birgenair Flight 301 is scheduled to fly from Puerto Plata to Frankfurt. On takeoff, the captain finds that his airspeed indicator (ASI) is not reading properly, though the co-pilot's ASI is showing the correct speed; the aircraft subsequently crashes in the Atlantic Ocean. The pilots became confused and believed that both ASIs were malfunctioning, leading to loss of control of the aircraft. All 13 crew members and 176 passengers died. The cause of the disaster was believed to be a wasp that built a nest in one of the aircraft's pitot tubes, which was incorrectly left uncovered during the aircraft's extended stay at Puerto Plata airport.

Near the close of the Vietnam War, the United States launched Operation Babylift, a mass evacuation of children from war torn Vietnam. On April 4th 1975, the first Babylift flight ended in tragedy when a Lockheed C-5 Galaxy carrying 314 passengers crashed during an emergency landing at Tan Son Nhut Air Base, South Vietnam killing 138.

On 12 May 1989, a 69-car freight train goes out of control while descending from California's Cajon Pass. It derails in a residential neighbourhood of San Bernardino after reaching speeds in excess of 100 miles per hour (160 km/h). Two residents and two train crew members are killed in the initial crash. More than a week later, an underground gasoline pipeline, damaged by earth-moving equipment during the post-crash clean-up, ruptures and sparks a fire that kills another two people. A clerical error had caused the train's weight to be greatly underestimated, and it had been assembled without enough locomotives to provide adequate braking. Additionally, several of the engines had completely inoperable brakes, but this information was not passed on to the crews.

Note: This is a Crash Scene Investigation episode.

On 18 June 1972, British European Airways Flight 548 stalls and crashes in a field near Staines-upon-Thames shortly after takeoff from London Heathrow Airport, killing all 118 people on board. The crash was attributed to the pilot retracting the aircraft's droops at too low an airspeed and failing to recognise the stall warnings.

On 13 January 1982, Air Florida Flight 90 takes off from a snowy runway in Washington D.C, stalls at 300 feet altitude, strikes a road bridge and crashes into the Potomac River, killing a total of 78 people. The causes were ice on the wings and the pilots' failure to turn on the engines' anti-freeze system, causing erroneous engine instrument readings.

On 12 November 2001, just two months after the September 11 attacks, American Airlines Flight 587 spirals out of control after taking off from John F. Kennedy Airport. Shortly after, the aircraft crashes into the suburb of Queens, killing all 260 people on board and five people on the ground. The vertical stabilizer had detached from the aircraft because of improper rudder use by the first officer, after encountering wake turbulence from a Boeing 747-400 that had taken off minutes earlier.

On 15 September 1989, a National Oceanic and Atmospheric Administration aircraft tasked with intercepting Hurricane Hugo over the Caribbean islands is jolted by strong winds, causing an engine to catch fire and fail. The pilots of the aircraft manage to make a safe emergency landing.

On 8 January 1989, British Midland Flight 92 crashes onto the embankment of the M1 motorway near Kegworth, Leicestershire, UK. The aircraft was attempting to conduct an emergency landing at East Midlands Airport. Of the 126 people aboard, 47 died and 74, including seven members of the flight crew, sustained serious injuries.

On 26 May 1991, the thrust reverser of the first engine of Lauda Air Flight 004 accidentally deploys in mid-flight causing the plane to spiral out of control and disintegrate about 100 miles northwest of Bangkok. All of the 223 passengers and crew die in the crash.

On 16 July 1999, John F. Kennedy Jr. dies when the Piper Saratoga light aircraft he is piloting crashes into the Atlantic Ocean off the coast of Martha's Vineyard, Massachusetts, in hazy conditions. His wife, Carolyn Bessette-Kennedy, and sister-in-law, Lauren Bessette, are on board and are also killed. The NTSB concluded that the crash was caused by spatial disorientation resulting in pilot error.

On 3 September 1989, the pilots of Varig Flight 254 enter an incorrect heading into the flight computer. Instead of flying towards its destination, the aircraft flies west and after some time is over a remote area of the Amazon jungle. Attempts to reach an alternative airport are unsuccessful, and the aircraft eventually runs out of fuel. The pilot makes a belly landing in the jungle where 13 people die.

On 10 February 2011, Manx2 Flight 7100 crashes at Cork Airport in Ireland after the pilots lose control of the aircraft in an attempted go-around in low visibility. Six of the twelve people on board are killed in the crash.

On 8 March 2014, Malaysia Airlines Flight 370 disappears en route from Kuala Lumpur to Beijing with 239 passengers and crew on board. As of February 2015, no trace of the Boeing 777-200ER had been found, and speculation is that it crashed in the southern part of the Indian Ocean.

Copa Airlines Flight 201 is flying towards Cali, Colombia when the plane suddenly disintegrates in mid-air.

FedEx Express Flight 14 crash lands at Newark but the pilots survive but years later, FedEx Express Flight 80 experiences a similar but fatal crash.

On 20 August 2011, First Air Flight 6560, a charter flight, crashes near its destination of Resolute Bay Airport, Resolute, Nunavut, Canada, in poor weather conditions. Out of the fifteen passengers and crew members, only three survived.

On 19 November 1996, United Express Flight 5925, operating for Great Lakes Airlines, lands at Quincy Regional Airport and collides with a light aircraft taking off from an intersecting runway. All 14 occupants on both aircraft were killed in a subsequent fire.

On 7 March 2007, while landing at Yogyakarta at the end of a routine domestic flight from Jakarta, Garuda Indonesia Flight 200 hits the ground so hard that it bounces violently before running off the end of the runway, killing 21 of the 140 people on board.

On 3 September 2010, the pilots of UPS Airlines Flight 6 report a fire and declare an emergency shortly after taking off from Dubai International Airport. The crew tries to land back at the airport, but are unsuccessful. The aircraft flies over the airport and crashes into an unpopulated area nearby. Both of the pilots die.

On 6 July 2013, on landing at San Francisco International Airport, Asiana Airlines Flight 214 strikes a seawall and crashes short of the runway. Of the 307 people on board, 2 passengers die at the crash scene; another dies shortly after in hospital.

On 4 October 1992, after taking off from Amsterdam Airport Schiphol, El Al Flight 1862 declares an emergency. The crew do their best to make an emergency landing, but the 747 cargo jet rolls violently to the right and crashes into an apartment complex, killing 43 people. The two engines on the right wing had separated from the aircraft, causing the loss of control.

On 5 April 1991, Atlantic Southeast Airlines Flight 2311 from Atlanta suddenly nose-dives into the ground while on landing approach to Glynco Jetport, killing all 23 people on board, including US Senator John Tower and astronaut Sonny Carter. The accident was caused by a malfunction of the left engine propeller control unit.

On 31 October 1996, TAM Transportes Aéreos Regionais Flight 402 crashes seconds after takeoff from São Paulo–Congonhas Airport into a heavily populated residential area, killing all 96 people on board and 3 on the ground. The crash was attributed to the uncommanded deployment of a faulty thrust reverser on the right engine.

On 10 October 2006, Atlantic Airways Flight 670 lands at Stord Airport, but the aircraft overruns the runway and crashes after careening off a steep embankment. Four of the sixteen people on board are killed. The causes of the crash were a malfunction of the aircraft's spoilers and hydroplaning.

On 18 September 1961, a Douglas DC-6 operated by Transair Sweden, carrying Dag Hammarskjöld, the second Secretary-General of the United Nations, crashes en route to cease-fire negotiations in Northern Rhodesia during the Congo Crisis. All of the 16 passengers and crew members are killed.

On 20 August 2008, Spanair Flight 5022 attempts to takeoff from Barajas Airport, but stalls immediately, banks to the right and crashes, killing 154 people out of the 172 on board. The pilots aborted the first takeoff attempt, and the second attempt resulted in the crash.

On 11 September 2001, during the September 11 attacks, American Airlines Flight 77 flies off course and crashes into the Pentagon in Arlington County, Virginia, after being hijacked. All the 64 people on board the aircraft, including the 5 hijackers, are killed, along with 125 people in the building.

On 27 March 1977, the deadliest-ever aviation accident occurs at Los Rodeos Airport (now known as Tenerife-North Airport) in the Canary Islands. KLM Flight 4805 and Pan Am Flight 1736 collide on the runway in thick fog during the KLM aircraft's attempt to take off, killing 583 people.

On 20 August 2007, China Airlines Flight 120 catches fire and explodes shortly after landing and taxiing to the gate area at Naha Airport in Okinawa, Japan. All of the 165 passengers and crew members survive.

On 30 July 1998, Proteus Airlines Flight 706 collides with a light aircraft during a detour over an ocean cruise liner and crashes into Quiberon Bay off the coast of Lorient, France. All fifteen occupants on board the two aircraft are killed.

On 19 January 1988, Trans-Colorado Airlines Flight 2286, operating for Continental Express, crashes near Bayfield, Colorado, while on final approach to Durango. Both crew members and seven of the fifteen passengers on board die.

On 24 March 2015, Germanwings Flight 9525 enters a high-speed descent and crashes into the French Alps during a flight from Barcelona, Spain, to Düsseldorf, Germany. All 150 people on board are killed.

After a routine one-hour flight from Minneapolis, Northwest Airlink Flight 5719 crashes in northern Minnesota, killing everyone on board. Investigators face intense pressure to find the cause. The cockpit voice recorder raises disturbing questions about an inexperienced pilot. But as investigators dig deeper, they uncover a troubling pattern of abuse that led to a breakdown in human cooperation.

When a commuter flight to Detroit ends in a harrowing death spiral, it's up to investigators to determine the cause and prevent it from ever happening again. They sort through the shattered wreckage in search of clues, and a close analysis of the flight data eventually leads them to a stunning realization-What doomed Flight 3272 is a danger the industry has known about for years.

Headed for South Korea's Gimhae International Airport, a Boeing 767 crashes into a hillside several miles from the runway. As the nation mourns its worst-ever air disaster, investigators face puzzling evidence: The surviving captain of Air China Flight 129 claims that everything on board was normal, but air traffic controllers testify that the crew's radio communications were anything but.

Just minutes after taking off from New York's JFK Airport, TWA Flight 800 is ripped apart by a massive explosion. With a possible terror attack on their hands, the FBI joins investigators from the NTSB in an urgent search for answers. Both agencies are hoping for quick results, but the investigation into TWA Flight 800 will eventually pit them against one another, and will turn into one of the longest, most costly and challenging ever conducted.

On 26 September 1997, Garuda Indonesia Flight 152 crashes into mountainous woodlands while trying to land at Polonia International Airport in Medan, North Sumatra, in low visibility. All 234 people on board are killed.

On 16 February 2000, Emery Worldwide Flight 17 crashes into an automobile salvage yard shortly after taking off from Sacramento Mather Airport on a flight to Dayton, Ohio, killing all 3 crew members on board.

On 23 July 2014, TransAsia Airways Flight 222 crashes into buildings while attempting to land at Magong Airport during inclement weather and low visibility, killing 48 of the 58 people on board.

On 31 August 1988, Delta Air Lines Flight 1141 crashes beyond the runway while taking off from Dallas/Fort Worth International Airport, killing 14 of the 108 people on board.

On 17 July 2014, Malaysia Airlines Flight 17 disintegrates in mid-air and crashes while en route from Amsterdam to Kuala Lumpur, killing all 283 passengers and 15 crew members on board.

On 9 May 2012, an aircraft on a demonstration tour crashes into Mount Salak in the province of West Java. All 45 people on board are killed.

(Uni Air Flight 873) Experts fail to find a bomb when a Taiwanese plane explodes. But as they examine the wreckage, they uncover something shocking in the overhead lockers.

(Northwest Airlines Flights 299 & 1482) When a blanket of confusion and heavy fog puts two planes on a path to disaster, investigators wonder if it was the pilots themselves creating chaos.

(SOL Flight 5428) When SOL Airlines Flight 5428 nosedives into a remote desert, investigators struggle to find the cause amongst the scattered and scorched debris.

(Cougar Helicopters Flight 91) A helicopter carrying offshore oil workers crashes into the ocean off the coast of Newfoundland and a far-reaching investigation reveals a fatal flaw.

(AIRES Flight 8250) On 16 August 2010, AIRES Flight 8250 crashes short of the runway while attempting to land at San Andrés, Colombia in a storm. The aircraft broke up into 3 pieces on the runway. 2 of the passengers died in the accident.

On 12 March 2018, US-Bangla Airlines Flight 211 skids off the runway, travels through the airport perimeter fence, and crashes into a football field during landing at Tribhuvan International Airport in Kathmandu, Nepal. 51 of the 71 people on board are killed in the accident.

On 22 February 1991, a military aerial refueling aircraft loses both engines from under the left wing while on a combat mission in Saudi Arabia during the Gulf War, causing serious flight control problems and forcing the pilots to make an emergency landing.

On 9 June 1995, Ansett New Zealand Flight 703 suffers a landing gear malfunction during final approach to Palmerston North Airport in New Zealand. The aircraft descends until it crashes into hilly terrain as the pilots try to resolve the problem. 4 of the 21 people on board are killed.

When Alaska Airlines Flight 261 suddenly nosedives into the Pacific, investigators uncover a critical maintenance issue with deadly implications.

After a Boeing 727's near-fatal nosedive over Michigan, investigators risk their own lives to determine why TWA Flight 841 fell out of the sky.

Rocked by an explosion that rips both right wing engines off the wing, the pilots of Transair 671 manage a miraculous landing at a French military airfield.

Facing a severe thunderstorm and a control tower shutdown, American Airlines 1572 suffers double-engine failure on final approach into Windsor Locks Airport in Connecticut.

A turboprop, Air Illinois Flight 710, crashes in bad weather, and investigators eventually uncover a fatal assumption and deadly decision.