Ex-employee of Stark Industries, Dr. Jonathan Ohn, invents a portable interdimensional technology that accidentally makes him the living embodiment of a portal. Calling himself the Spot, he tries to steal money to fund his research. But his unstable invention has created a vortex that threatens to engulf New York.

When Dr. Ohn's Time Dilation Accelerator falls into the wrong hands, all the criminal minds of the city vie for the portal technology. Peter and Mary Jane are celebrating Felicia Hardy's engagement to Jason Macendale when they overhear plans for a major heist.

Peter Parker and Mary Jane are finally a couple, but their happiness is short-lived as the Green Goblin, armed with a Time Distorter and the true identity of Spider-Man, seeks to destroy the web-slinger by any means necessary.

Spider-Man captures a gang of thieves, and it looks like Robbie Robertson is their leader. Peter Parker and J. Jonah Jameson must team up to try to clear Robbie's name. But while Jameson returns to the skills he had as an investigative reporter, Peter must keep him safe from Tombstone.

Harry Osborn is haunted by dreams of his father, the Green Goblin, and Spider-Man. The Goblin visits him and guides him to the Goblin formula and weapons. Meanwhile, the Punisher promises Anna Watson that he will find Mary Jane, and on top of his list of suspects is Peter Parker.