With Pope Pius XIII in a coma, Cardinal Voiello makes an unpredictable move during the deadlocked papal conclave.

Voiello, Guiterrez, Assente, Aguirre and Sofia make a trip to the UK to appeal to the alluring but fragile Sir John Brannox.

As Sir John leaves for the Vatican, everything appears to be going to plan. But the secretary of state could never have predicted Cardinal Spalletta's next move.

John Paul III travels to Venice to visit Pius XIII. Meanwhile, a tragedy in Lourdes calls for the presence of the new Pope.

John Paul III meets Sharon Stone, who gives him new ideas. Meanwhile, the connection between the Pope and Sofia deepens.