On the eve of the worst crisis in human history, Congresswoman Jennifer Brown clashes with the President. Her children Yorick and Hero reach an emotional crossroads. None of them know their lives are about to change forever.

After a mass casualty event wipes out every creature with a Y chromosome, President Jennifer Brown responds to the crisis. Yorick fears he may be the only survivor. Hero attempts to right a wrong.

Kimberly uncovers a secret. 355 and Allison reach an understanding. Yorick stumbles upon a mysterious town where things are not what they seem.

Tensions at the PriceMax spiral out of control. Hero and Sam pass the point of no return. Nora uncovers dangerous secrets.

As tensions at the Pentagon come to a head, Jennifer faces a threat. The Amazons hit the road.

As the Amazons close in on Marrisville, Nora reaches a breaking point. Yorick makes a new connection while 355 faces her past.