In 1982, two families, the Sanders and the Landrys, are badly shaken when they learn that a mysterious deadly disease called AIDS is threatening the blood system. Each has boys with hemophilia, a genetic condition that means they depend on blood products to live. The medical community struggles to understand the growing epidemic while others deny the urgency.

With his son's life hanging in the balance, Will Sanders desperately fights to get those in charge of blood safety to heed the danger. The Landry's struggle to keep their family together after their son, Peter, distraught that he is likely infected with AIDS, leaves home. Dr. Christos Tsoukas publishes results of a study that suggests fifty percent of all hemophiliacs in Canada are HIV positive.